EC 1.14.14.56 - 1,8-cineole 2-exo-monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.14.56

Names

Accepted name:
1,8-cineole 2-exo-monooxygenase
Other name:
CYP3A4
Systematic name:
1,8-cineole,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (2-exo-hydroxylating)

Reaction

Cofactor

Comments:

A cytochrome P-450 (heme-thiolate) protein. The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.14.55, quinine 3-monooxygenase, EC 1.14.14.57, taurochenodeoxycholate 6-hydroxylase and EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102320
UniProtKB/Swiss-Prot:

References

  1. Miyazawa, M., Shindo, M., Shimada, T.
    Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.
    Drug Metab. Dispos. 29: 200-205 (2001). [PMID: 11159812]
  2. Miyazawa, M., Shindo, M.
    Biotransformation of 1,8-cineole by human liver microsomes.
    Nat Prod Lett 15: 49-53 (2001). [PMID: 11547423]
  3. Miyazawa, M., Shindo, M., Shimada, T.
    Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.
    Xenobiotica 31: 713-723 (2001). [PMID: 11695850]

[EC 1.14.14.56 created 2012 as EC 1.14.13.157, transferred 2017 to EC 1.14.14.56]