EC 1.14.14.53 - (R)-limonene 6-monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.14.53

Names

Accepted name:
(R)-limonene 6-monooxygenase
Other names:
(+)-limonene 6-monooxygenase
(+)-limonene-6-hydroxylase
Systematic name:
(R)-limonene,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)

Reaction

Cofactor

Comments:

The reaction is stereospecific with over 95% yield of (+)-trans-carveol from (R)-limonene. (S)-Limonene, the substrate for EC 1.14.14.51, (S)-limonene 6-monooxygenase, is not a substrate. Forms part of the carvone biosynthesis pathway in Carum carvi (caraway) seeds.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052741
CAS Registry Number: 221461-49-0
UniProtKB/Swiss-Prot:

References

  1. Bouwmeester, H.J., Gershenzon, J., Konings, M.C.J.M. and Croteau, R.
    Biosynthesis of the monoterpenes limonene and carvone in the fruit of caraway. I. Demonstration of enzyme activities and their changes with development.
    Plant Physiol. 117 : 901-912 (1998). [PMID: 9662532]
  2. Bouwmeester, H.J., Konings, M.C.J.M., Gershenzon, J., Karp, F. and Croteau, R.
    Cytochrome P-450 dependent (+)-limonene-6-hydroxylation in fruits of caraway (Carum Carvi).
    Phytochemistry 50 : 243-248 (1999).

[EC 1.14.14.53 created 2003 as EC 1.14.13.80, transferred 2017 to EC 1.14.14.53]