EC 1 - Oxidoreductases
EC 1.14 - Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2
EC 1.14.14 - With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
EC 1.14.14.51 - (S)-limonene 6-monooxygenase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.14.14.51
Names
Accepted name:
(S)-limonene 6-monooxygenase
Other
names:
(−)-limonene 6-hydroxylase
(−)-limonene 6-monooxygenase
(−)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
(−)-limonene 6-monooxygenase
(−)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
Systematic name:
(S)-limonene,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)
Reaction
- (S)-limonene + reduced NADPHhemoprotein reductase + O2 = ()-trans-carveol + oxidized NADPHhemoprotein reductase + H2O
Cofactor
Comments:
A cytochrome P450 (heme thiolate) enzyme. The enzyme participates in the biosynthesis of (−)-carvone, which is responsible for the aroma of spearmint.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UM-BBD
,
UniPathway
Protein domains and families:
PROSITE:PDOC00081
Gene Ontology:
GO:0018675
CAS Registry Number:
138066-93-0
References
-
Monoterpene biosynthesis: specificity of the hydroxylations of (−)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves.Arch. Biochem. Biophys. 276 : 219-226 (1990). [PMID: 2297225]
[EC 1.14.14.51 created 1992 as 1.14.13.48, modified 2003, transferred 2017 to EC 1.14.14.51]