EC - (S)-limonene 6-monooxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
(S)-limonene 6-monooxygenase
Other names:
(−)-limonene 6-hydroxylase
(−)-limonene 6-monooxygenase
(−)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
Systematic name:
(S)-limonene,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)




A cytochrome P450 (heme thiolate) enzyme. The enzyme participates in the biosynthesis of (−)-carvone, which is responsible for the aroma of spearmint.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018675
CAS Registry Number: 138066-93-0
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. Karp, F., Mihaliak, C.A., Harris, J.L. and Croteau, R.
    Monoterpene biosynthesis: specificity of the hydroxylations of (−)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves.
    Arch. Biochem. Biophys. 276 : 219-226 (1990). [PMID: 2297225]

[EC created 1992 as, modified 2003, transferred 2017 to EC]