EC - Methanesulfonate monooxygenase (FMNH2)

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IntEnz Enzyme Nomenclature


Accepted name:
methanesulfonate monooxygenase (FMNH2)
Other names:
msuD (gene name)
ssuD (gene name)
Systematic name:
methanesulfonate,FMNH2:oxygen oxidoreductase



The enzyme, characterized from Pseudomonas strains, allows the organisms to utilize methanesulfonate as their sulfur source. It acts in combination with a dedicated NADH-dependent FMN reductase (EC, which provides it with reduced FMN. cf. EC, methanesulfonate monooxygenase (NADH).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Kertesz, M. A., Schmidt-Larbig, K., Wuest, T.
    A novel reduced flavin mononucleotide-dependent methanesulfonate sulfonatase encoded by the sulfur-regulated msu operon of Pseudomonas aeruginosa.
    J. Bacteriol. 181 : 1464-1473 (1999). [PMID: 10049377]
  2. Endoh, T., Kasuga, K., Horinouchi, M., Yoshida, T., Habe, H., Nojiri, H., Omori, T.
    Characterization and identification of genes essential for dimethyl sulfide utilization in Pseudomonas putida strain DS1.
    Appl. Microbiol. Biotechnol. 62 : 83-91 (2003). [PMID: 12835925]

[EC created 2016]