EC 1.14.14.23 - Cholesterol 7α-monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.14.23

Names

Accepted name:
cholesterol 7α-monooxygenase
Other names:
cholesterol 7α-hydroxylase
CYP7A1
Systematic name:
cholesterol,NADPH—hemoprotein reductase:oxygen oxidoreductase (7α-hydroxylating)

Reaction

Cofactor

Comments:

A P-450 heme-thiolate liver protein that catalyses the first step in the biosynthesis of bile acids. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH—hemoprotein reductase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008123
CAS Registry Number: 9037-53-0
UniProtKB/Swiss-Prot:

References

  1. Mitton, J. R., Scholan, N. A., Boyd, G. S.
    The oxidation of cholesterol in rat liver sub-cellular particles. The cholesterol-7α-hydroxylase enzyme system.
    Eur. J. Biochem. 20: 569-579 (1971). [PMID: 4397276]
  2. Boyd, G. S., Grimwade, A. M., Lawson, M. E.
    Studies on rat-liver microsomal cholesterol 7α-hydroxylase.
    Eur. J. Biochem. 37: 334-340 (1973). [PMID: 4147676]
  3. Ogishima, T., Deguchi, S. and Okuda, K.
    Purification and characterization of cholesterol 7α-hydroxylase from rat liver microsomes.
    J. Biol. Chem. 262: 7646-7650 (1987). [PMID: 3584134]
  4. Nguyen, L. B., Shefer, S., Salen, G., Ness, G., Tanaka, R. D., Packin, V., Thomas, P., Shore, V., Batta, A.
    Purification of cholesterol 7 alpha-hydroxylase from human and rat liver and production of inhibiting polyclonal antibodies.
    J. Biol. Chem. 265: 4541-4546 (1990). [PMID: 2106520]
  5. Nguyen, L. B., Shefer, S., Salen, G., Chiang, J. Y., Patel, M.
    Cholesterol 7alpha-hydroxylase activities from human and rat liver are modulated in vitro posttranslationally by phosphorylation/dephosphorylation.
    Hepatology 24: 1468-1474 (1996). [PMID: 8938182]

[EC 1.14.14.23 created 1976 as EC 1.14.13.17, transferred 2016 to EC 1.14.14.23]