EC - Ferruginol synthase

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IntEnz Enzyme Nomenclature


Accepted name:
ferruginol synthase
Other names:
miltiradiene oxidase [incorrect]
miltiradiene,NADPH:oxygen oxidoreductase (ferruginol forming) [incorrect]
Systematic name:
abieta-8,11,13-triene,[reduced NADPH—hemoprotein reductase]:oxygen 12-oxidoreductase (ferruginol-forming)



A cytochrome P450 (heme thiolate) enzyme found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Guo, J., Zhou, Y. J., Hillwig, M. L., Shen, Y., Yang, L., Wang, Y., Zhang, X., Liu, W., Peters, R. J., Chen, X., Zhao, Z. K., Huang, L.
    CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.
    Proc. Natl. Acad. Sci. U.S.A. 110 : 12108-12113 (2013). [PMID: 23812755]
  2. Zi, J., Peters, R. J.
    Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae.
    Org. Biomol. Chem. 11 : 7650-7652 (2013). [PMID: 24108414]
  3. Bozic, D., Papaefthimiou, D., Bruckner, K., de Vos, R. C., Tsoleridis, C. A., Katsarou, D., Papanikolaou, A., Pateraki, I., Chatzopoulou, F. M., Dimitriadou, E., Kostas, S., Manzano, D., Scheler, U., Ferrer, A., Tissier, A., Makris, A. M., Kampranis, S. C., Kanellis, A. K.
    Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis.
    PLoS ONE 10 : e0124106 (2015). [PMID: 26020634]

[EC created 2014 as EC, modified 2015, transferred 2020 to EC]