EC 1.14.14.175 - Ferruginol synthase

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IntEnz Enzyme Nomenclature
EC 1.14.14.175

Names

Accepted name:
ferruginol synthase
Other names:
miltiradiene oxidase [incorrect]
CYP76AH1
miltiradiene,NADPH:oxygen oxidoreductase (ferruginol forming) [incorrect]
Systematic name:
abieta-8,11,13-triene,[reduced NADPH—hemoprotein reductase]:oxygen 12-oxidoreductase (ferruginol-forming)

Reaction

Comments:

A cytochrome P450 (heme thiolate) enzyme found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant. Formerly EC 1.14.13.190.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Guo, J., Zhou, Y. J., Hillwig, M. L., Shen, Y., Yang, L., Wang, Y., Zhang, X., Liu, W., Peters, R. J., Chen, X., Zhao, Z. K., Huang, L.
    CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.
    Proc. Natl. Acad. Sci. U.S.A. 110 : 12108-12113 (2013). [PMID: 23812755]
  2. Zi, J., Peters, R. J.
    Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae.
    Org. Biomol. Chem. 11 : 7650-7652 (2013). [PMID: 24108414]
  3. Bozic, D., Papaefthimiou, D., Bruckner, K., de Vos, R. C., Tsoleridis, C. A., Katsarou, D., Papanikolaou, A., Pateraki, I., Chatzopoulou, F. M., Dimitriadou, E., Kostas, S., Manzano, D., Scheler, U., Ferrer, A., Tissier, A., Makris, A. M., Kampranis, S. C., Kanellis, A. K.
    Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis.
    PLoS ONE 10 : e0124106 (2015). [PMID: 26020634]

[EC 1.14.14.175 created 2014 as EC 1.14.13.190, modified 2015, transferred 2020 to EC 1.14.14.175]