EC 1.14.14.173 - 2,4,6-trichlorophenol monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.14.173

Names

Accepted name:
2,4,6-trichlorophenol monooxygenase
Systematic name:
2,4,6-trichlorophenol,FADH2:oxygen oxidoreductase (dechlorinating)

Reactions

Comments:

The enzyme, characterized from a number of bacterial species, participates in the degradation of 2,4,6-trichlorophenol, a compound that has been used for decades as a wood preservative. The enzyme is a multifunctional flavin-dependent monooxygenase that displaces two chlorine atoms by attacking two different positions in the substrate. Each reaction catalysed by the enzyme displaces a single chlorine and results in formation of a dione, which must be reduced by FADH2 before the monooxygenase could catalyse the second reaction. The large amount of FADH2 that is required is generated by a dedicated flavin reductase (TcpB). Cf. EC 1.14.14.172.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Louie, T. M., Webster, C. M., Xun, L.
    Genetic and biochemical characterization of a 2,4,6-trichlorophenol degradation pathway in Ralstonia eutropha JMP134.
    J. Bacteriol. 184 : 3492-3500 (2002). [PMID: 12057943]

[EC 1.14.14.173 created 2020]