EC 1.14.14.17 - Squalene monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.14.17

Names

Accepted name:
squalene monooxygenase
Other names:
squalene 2,3-oxidocyclase
squalene epoxidase
squalene hydroxylase
squalene oxydocyclase
squalene-2,3-epoxidase
squalene-2,3-epoxide cyclase
Systematic name:
squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing)

Reaction

Cofactor

Comments:

A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH—hemoprotein reductase [5,7].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004506
CAS Registry Number: 9029-62-3
UniProtKB/Swiss-Prot: (19) [show] [UniProt]

References

  1. Corey, E.J., Russey, W.E. and Ortiz de Montellano, P.R.
    2,3-Oxidosqualene, an intermediate in the biological synthesis of sterols from squalene.
    J. Am. Chem. Soc. 88 : 4750-4751 (1966). [PMID: 5918046]
  2. Tchen, T.T. and Bloch, K.
    On the conversion of squalene to lanosterol in vitro.
    J. Biol. Chem. 226 : 921-930 (1957). [PMID: 13438881]
  3. van Tamelen, E.E., Willett, J.D., Clayton, R.B. and Lord, K.E.
    Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol.
    J. Am. Chem. Soc. 88 : 4752-4754 (1966). [PMID: 5918048]
  4. Yamamoto, S. and Bloch, K.
    Studies on squalene epoxidase of rat liver.
    J. Biol. Chem. 245 : 1670-1674 (1970). [PMID: 5438357]
  5. Ono, T., Bloch, K.
    Solubilization and partial characterization of rat liver squalene epoxidase.
    J. Biol. Chem. 250 : 1571-1579 (1975). [PMID: 234459]
  6. Satoh, T., Horie, M., Watanabe, H., Tsuchiya, Y., Kamei, T.
    Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae.
    Biol. Pharm. Bull. 16 : 349-352 (1993). [PMID: 8358382]
  7. Chugh, A., Ray, A., Gupta, J. B.
    Squalene epoxidase as hypocholesterolemic drug target revisited.
    Prog. Lipid Res. 42 : 37-50 (2003). [PMID: 12467639]
  8. He, F., Zhu, Y., He, M., Zhang, Y.
    Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng.
    DNA Seq. 19 : 270-273 (2008). [PMID: 17852349]

[EC 1.14.14.17 created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, part transferred 1972 to EC 1.14.99.7, transferred 2011 to EC 1.14.13.132]