EC 1.14.14.166 - (S)-N-methylcanadine 1-hydroxylase

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IntEnz Enzyme Nomenclature
EC 1.14.14.166

Names

Accepted name:
(S)-N-methylcanadine 1-hydroxylase
Other name:
CYP82Y1
Systematic name:
(S)-N-methylcanadine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (1-hydroxylating)

Reaction

Comments:

This cytochrome P450 (heme-thiolate) enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Dang, T. T., Facchini, P. J.
    CYP82Y1 is N-methylcanadine 1-hydroxylase, a key noscapine biosynthetic enzyme in opium poppy.
    J. Biol. Chem. 289 : 2013-2026 (2014). [PMID: 24324259]
  2. Li, Y., Li, S., Thodey, K., Trenchard, I., Cravens, A., Smolke, C. D.
    Complete biosynthesis of noscapine and halogenated alkaloids in yeast.
    Proc. Natl. Acad. Sci. U.S.A. 115 : E3922-E3931 (2018). [PMID: 29610307]

[EC 1.14.14.166 created 2018]