EC - Indole-3-carbonyl nitrile 4-hydroxylase

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IntEnz Enzyme Nomenclature


Accepted name:
indole-3-carbonyl nitrile 4-hydroxylase
Other name:
Systematic name:
indole-3-carbonyl nitrile,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)



A cytochrome P450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana. Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense. The enzyme also catalyses the 5-hydroxylation of xanthotoxin [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0106149


  1. Kruse, T., Ho, K., Yoo, H. D., Johnson, T., Hippely, M., Park, J. H., Flavell, R., Bobzin, S.
    In planta biocatalysis screen of P450s identifies 8-methoxypsoralen as a substrate for the CYP82C subfamily, yielding original chemical structures.
    Chem. Biol. 15 : 149-156 (2008). [PMID: 18291319]
  2. Rajniak, J., Barco, B., Clay, N. K., Sattely, E. S.
    A new cyanogenic metabolite in Arabidopsis required for inducible pathogen defence.
    Nature 525 : 376-379 (2015). [PMID: 26352477]

[EC created 2018]