EC 1.14.14.163 - (S)-1-hydroxy-N-methylcanadine 13-hydroxylase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.14.14.163

Names

Accepted name:
(S)-1-hydroxy-N-methylcanadine 13-hydroxylase
Other name:
CYP82X2
Systematic name:
(S)-1-hydroxy-N-methylcanadine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (13-hydroxylating)

Reaction

Comments:

The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Dang, T. T., Chen, X., Facchini, P. J.
    Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.
    Nat. Chem. Biol. 11: 104-106 (2015). [PMID: 25485687]
  2. Li, Y., Smolke, C. D.
    Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.
    Nat Commun 7: 12137 (2016). [PMID: 27378283]
  3. Li, Y., Li, S., Thodey, K., Trenchard, I., Cravens, A., Smolke, C. D.
    Complete biosynthesis of noscapine and halogenated alkaloids in yeast.
    Proc. Natl. Acad. Sci. U.S.A. 115: E3922-E3931 (2018). [PMID: 29610307]

[EC 1.14.14.163 created 2018]