EC 1.14.14.14 - Aromatase

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IntEnz Enzyme Nomenclature
EC 1.14.14.14

Names

Accepted name:
aromatase
Other names:
CYP19A1
estrogen synthetase [incorrect]
Systematic name:
testosterone monooxygenase (17β-estradiol-forming)

Reactions

Comments:

A cytochrome P450. The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17β-estradiol, respectively.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (24) [show] [UniProt]

References

  1. Thompson, E. A., Siiteri, P. K.
    The involvement of human placental microsomal cytochrome P-450 in aromatization.
    J. Biol. Chem. 249: 5373-5378 (1974). [PMID: 4370479]
  2. Fishman, J., Goto, J.
    Mechanism of estrogen biosynthesis. Participation of multiple enzyme sites in placental aromatase hydroxylations.
    J. Biol. Chem. 256: 4466-4471 (1981). [PMID: 7217091]
  3. Kellis, J. T., Vickery, L. E.
    Purification and characterization of human placental aromatase cytochrome P-450.
    J. Biol. Chem. 262: 4413-4420 (1987). [PMID: 3104339]
  4. Ghosh, D., Griswold, J., Erman, M., Pangborn, W.
    Structural basis for androgen specificity and oestrogen synthesis in human aromatase.
    Nature 457: 219-223 (2009). [PMID: 19129847]

[EC 1.14.14.14 created 2013]