EC 1.14.14.138 - Lithocholate 6β-hydroxylase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.14.14.138

Names

Accepted name:
lithocholate 6β-hydroxylase
Other names:
lithocholate 6β-monooxygenase
CYP3A10
6β-hydroxylase
cytochrome P450 3A10
lithocholic acid 6β-hydroxylase
Systematic name:
lithocholate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (6β-hydroxylating)

Reaction

Cofactor

Comments:

A cytochrome P450 (heme-thiolate) protein from Mesocricetus auratus (golden hamster). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters. Formerly EC 1.14.13.94.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033777
UniProtKB/Swiss-Prot:

References

  1. Teixeira, J. and Gil, G.
    Cloning, expression, and regulation of lithocholic acid 6β-hydroxylase.
    J. Biol. Chem. 266 : 21030-21036 (1991). [PMID: 1840595]
  2. Chang, T.K.H., Teixeira, J., Gil, G. and Waxman, D.J.
    The lithocholic acid 6β-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6β-hydroxylation.
    Biochem. J. 291 : 429-433 (1993). [PMID: 8484723]
  3. Subramanian, A., Wang, J. and Gil, G.
    STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6β-hydroxylase.
    Nucleic Acids Res. 26 : 2173-2178 (1998). [PMID: 9547277]
  4. Russell, D.W.
    The enzymes, regulation, and genetics of bile acid synthesis.
    Annu. Rev. Biochem. 72 : 137-174 (2003). [PMID: 12543708]

[EC 1.14.14.138 created 2005 as EC 1.14.13.94, transferred 2018 to EC 1.14.14.138]