EC 1.14.14.12 - 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.14.12

Names

Accepted name:
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
Other name:
HsaA
Systematic name:
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FADH2:oxygen oxidoreductase

Reaction

Comments:

This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone. It can use either FADH or FMNH2 as flavin cofactor. The enzyme forms a two-component system with a reductase (HsaB) that utilizes NADH to reduce the flavin, which is then transferred to the oxygenase subunit.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0036383
UniProtKB/Swiss-Prot:

References

  1. Dresen, C., Lin, L. Y., D'Angelo, I., Tocheva, E. I., Strynadka, N., Eltis, L. D.
    A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism.
    J. Biol. Chem. 285 : 22264-22275 (2010). [PMID: 20448045]

[EC 1.14.14.12 created 2011]