EC - Aflatoxin B synthase

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IntEnz Enzyme Nomenclature


Accepted name:
aflatoxin B synthase
Other name:
ordA (gene name)
Systematic name:
8-O-methylsterigmatocystin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (aflatoxin-B forming)




A cytochrome P450 (heme-thiolate) protein isolated from the mold Aspergillus parasiticus. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0140399


  1. Bhatnagar, D., Cleveland, T. E., Kingston, D. G.
    Enzymological evidence for separate pathways for aflatoxin B1 and B2 biosynthesis.
    Biochemistry 30 : 4343-4350 (1991). [PMID: 1902378]
  2. Yu, J., Chang, P. K., Ehrlich, K. C., Cary, J. W., Montalbano, B., Dyer, J. M., Bhatnagar, D., Cleveland, T. E.
    Characterization of the critical amino acids of an Aspergillus parasiticus cytochrome P-450 monooxygenase encoded by ordA that is involved in the biosynthesis of aflatoxins B1, G1, B2, and G2.
    Appl. Environ. Microbiol. 64 : 4834-4841 (1998). [PMID: 9835571]
  3. Udwary, D. W., Casillas, L. K., Townsend, C. A.
    Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis.
    J. Am. Chem. Soc. 124 : 5294-5303 (2002). [PMID: 11996570]

[EC created 2013 as EC, transferred 2018 to EC]