EC 1.14.14.114 - Amorpha-4,11-diene 12 monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.14.114

Names

Accepted name:
amorpha-4,11-diene 12 monooxygenase
Other name:
CYP71AV1
Systematic name:
amorpha-4,11-diene,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating)

Reaction

Cofactor

Comments:

A cytochrome P450 (heme-thiolate) protein. Cloned from the plant Artemisia annua (sweet wormwood). Part of the biosynthetic pathway of artemisinin. Formerly EC 1.14.13.158.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0062150
UniProtKB/Swiss-Prot:

References

  1. Teoh, K. H., Polichuk, D. R., Reed, D. W., Nowak, G., Covello, P. S.
    Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin.
    FEBS Lett. 580 : 1411-1416 (2006). [PMID: 16458889]

[EC 1.14.14.114 created 2012 as EC 1.14.13.158, transferred 2018 to EC 1.14.14.114]