EC - Kynurenine 3-monooxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
kynurenine 3-monooxygenase
Other names:
kynurenine 3-hydroxylase
kynurenine hydroxylase
Systematic name:
L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)




A flavoprotein (FAD). Formerly EC and

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004502
CAS Registry Number: 9029-61-2
UniProtKB/Swiss-Prot: (58) [show] [UniProt]


  1. de Castro, F.T., Price, J.M. and Brown, R.R.
    Reduced triphosphopyridinenucleotide requirement for the enzymatic formation of 3-hydroxykynurenine from L-kynurenine.
    J. Am. Chem. Soc. 78 : 2904-2905 (1956).
  2. Okamoto, H. and Hayaishi, O.
    Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria.
    Biochem. Biophys. Res. Commun. 29 : 394-399 (1967). [PMID: 6076241]
  3. Saito, Y., Hayaishi, O. and Rothberg, S.
    Studies on oxygenases: enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine.
    J. Biol. Chem. 229 : 921-934 (1957).

[EC created 1961 as EC, transferred 1965 to EC, transferred 1972 to EC]