EC - Anhydrotetracycline 6-monooxygenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
anhydrotetracycline 6-monooxygenase
Other names:
ATC oxygenase
anhydrotetracycline oxygenase
oxyS (gene name)
anhydrotetracycline monooxygenase
Systematic name:
anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)



The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. It can also catalyse EC, 12-dehydrotetracycline 5-monooxygenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047670
CAS Registry Number: 70766-62-0


  1. Behal, V.
    The tetracycline fermentation and its regulation.
    CRC Crit. Rev. Biotechnol. 5: 295-318 (1987).
  2. Binnie, C., Warren, M., Butler, M. J.
    Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis.
    J. Bacteriol. 171: 887-895 (1989). [PMID: 2914874]
  3. Vancurova, I., Volc, J., Flieger, M., Neuzil, J., Novotna, J., Vlach, J., Behal, V.
    Isolation of pure anhydrotetracycline oxygenase from Streptomyces aureofaciens.
    Biochem. J. 253: 263-267 (1988). [PMID: 3138982]
  4. Wang, P., Bashiri, G., Gao, X., Sawaya, M. R., Tang, Y.
    Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis.
    J. Am. Chem. Soc. 135: 7138-7141 (2013). [PMID: 23621493]

[EC created 1990, modified 2016]