EC 1.14.13.34 - Leukotriene-E4 20-monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.34

Names

Accepted name:
leukotriene-E4 20-monooxygenase
Other name:
leukotriene-E4 ω-hydroxylase
Systematic name:
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)

Reaction

Comments:

Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical with EC 1.14.13.30 leukotriene-B4 20-monooxygenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050052
CAS Registry Number: 111940-51-3

References

  1. Örning, L.
    ω-Oxidation of cysteine-containing leukotrienes by rat-liver microsomes. Isolation and characterization of ω-hydroxy and ω-carboxy metabolites of leukotriene E4 and N-acetylleukotriene E4.
    Eur. J. Biochem. 170 : 77-85 (1987). [PMID: 2826163]

[EC 1.14.13.34 created 1989]