EC - 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]

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IntEnz Enzyme Nomenclature


Accepted name:
4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
Other names:
4-hydroxybenzoate 3-hydroxylase
4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))
Systematic name:
4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)




A flavoprotein (FAD). The enzyme from Corynebacterium cyclohexanicum is highly specific for 4-hydroxybenzoate, but uses NADH and NADPH at approximately equal rates (cf. EC 4-hydroxybenzoate 3-monooxygenase). It is less specific for NADPH than EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018671
CAS Registry Number: 95471-33-3


  1. Fujii, T. and Kaneda, T.
    Purification and properties of NADH/NADPH-dependent p-hydroxybenzoate hydroxylase from Corynebacterium cyclohexanicum.
    Eur. J. Biochem. 147 : 97-104 (1985). [PMID: 3971979]
  2. Seibold, B., Matthes, M., Eppink, M.H., Lingens, F., Van Berkel, W.J. and Muller, R.
    4-Hydroxybenzoate hydroxylase from Pseudomonas sp. CBS3. Purification, characterization, gene cloning, sequence analysis and assignment of structural features determining the coenzyme specificity.
    Eur. J. Biochem. 239 : 469-478 (1996). [PMID: 8706756]

[EC created 1989, modified 1999]