EC 1.14.13.32 - Albendazole monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.32

Names

Accepted name:
albendazole monooxygenase
Other names:
albendazole oxidase [misleading]
albendazole sulfoxidase [ambiguous]
albendazole monooxygenase (flavin-containing) [ambiguous]
FMO3 (gene name)
Systematic name:
albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)

Reaction

Cofactor

Comments:

A microsomal flavin-containing monooxygenase. A similar conversion is also carried out by some microsomal cytochrome P450 enzymes [EC 1.14.14.73, albendazole monooxygenase (sufoxide-forming)]. It is estimated that cytochrome P450s are responsible for 70% of the activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047638
CAS Registry Number: 101299-59-6

References

  1. Fargetton, X., Galtier, P. and Delatour, P.
    Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes.
    Vet. Res. Commun. 10: 317-324 (1986). [PMID: 3739217]
  2. Moroni, P., Buronfosse, T., Longin-Sauvageon, C., Delatour, P., Benoit, E.
    Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes.
    Drug Metab. Dispos. 23: 160-165 (1995). [PMID: 7736906]
  3. Rawden, H. C., Kokwaro, G. O., Ward, S. A., Edwards, G.
    Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes.
    Br J Clin Pharmacol 49: 313-322 (2000). [PMID: 10759686]

[EC 1.14.13.32 created 1989, modified 2018]