IntEnz - EC 1.14.13.27

EC 1 - Oxidoreductases

EC 1.14 - Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O₂

EC 1.14.13 - With NADH or NADPH as one donor, and incorporation of one atom of oxygen

EC 1.14.13.27 - 4-aminobenzoate 1-monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.27

Names

Accepted name:

4-aminobenzoate 1-monooxygenase

Other names:

4-aminobenzoate hydroxylase
4-aminobenzoate monooxygenase
4-aminobenzoate dehydrogenase

Systematic name:

4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)

Reactions

11052 [IUBMB]

4-aminobenzoate

4-aminobenzoate

Name origin: UniProt - CHECKED (C)

CHEBI:17836

Formula: C7H6NO2
Charge: -1

ChEBI compound status: CHECKED (C)

+
2

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

NADH

NADH

Name origin: UniProt - CHECKED (C)

CHEBI:57945

Formula: C21H27N7O14P2
Charge: -2

ChEBI compound status: CHECKED (C)

+

O₂

O2

Name origin: UniProt - CHECKED (C)

CHEBI:15379

Formula: O2
Charge: 0

ChEBI compound status: CHECKED (C)

=

4-aminophenol

4-aminophenol

Name origin: UniProt - CHECKED (C)

CHEBI:17602

Formula: C6H7NO
Charge: 0

ChEBI compound status: CHECKED (C)

+

CO₂

CO2

Name origin: UniProt - CHECKED (C)

CHEBI:16526

Formula: CO2
Charge: 0

ChEBI compound status: CHECKED (C)

+

H₂O

H2O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

+

NAD⁺

NAD(+)

Name origin: UniProt - CHECKED (C)

CHEBI:57540

Formula: C21H26N7O14P2
Charge: -1

ChEBI compound status: CHECKED (C)
11056 [IUBMB]

4-aminobenzoate

4-aminobenzoate

Name origin: UniProt - CHECKED (C)

CHEBI:17836

Formula: C7H6NO2
Charge: -1

ChEBI compound status: CHECKED (C)

+
2

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

NADPH

NADPH

Name origin: UniProt - CHECKED (C)

CHEBI:57783

Formula: C21H26N7O17P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

O₂

O2

Name origin: UniProt - CHECKED (C)

CHEBI:15379

Formula: O2
Charge: 0

ChEBI compound status: CHECKED (C)

=

4-aminophenol

4-aminophenol

Name origin: UniProt - CHECKED (C)

CHEBI:17602

Formula: C6H7NO
Charge: 0

ChEBI compound status: CHECKED (C)

+

CO₂

CO2

Name origin: UniProt - CHECKED (C)

CHEBI:16526

Formula: CO2
Charge: 0

ChEBI compound status: CHECKED (C)

+

H₂O

H2O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

+

NADP⁺

NADP(+)

Name origin: UniProt - CHECKED (C)

CHEBI:58349

Formula: C21H25N7O17P3
Charge: -3

ChEBI compound status: CHECKED (C)

Cofactor

Comments:

A flavoprotein (FAD). Acts on anthranilate and 4-aminosalicylate but not on salicylate (cf. EC 1.14.13.1 salicylate 1-monooxygenase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0018670

CAS Registry Number: 98668-55-4

References

Tsuji, H., Ogawa, T., Bando, N. and Sasaoka, K.

Purification and properties of 4-aminobenzoate hydroxylase, a new monooxygenase from Agaricus bisporus.

J. Biol. Chem. 261: 13203-13209 (1986). [PMID: 3489713]

[EC 1.14.13.27 created 1989]