EC - Assimilatory dimethylsulfide S-monooxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
assimilatory dimethylsulfide S-monooxygenase
Systematic name:
dimethyl sulfide,NADH:oxygen oxidoreductase (S-oxidizing)



The enzyme, studied from the bacterium Acinetobacter sp. strain 20B, is very similar to EC, phenol 2-monooxygenase (NADH). It consists of a multisubunit oxygenease component that contains the active site and a dinuclear iron center, a reductase component that contains FAD and one iron-sulfur cluster, and a regulatory component. The three components comprise five different polypeptides. The enzyme catalyses the first two steps of a dimethyl sulfide oxidation pathway in this organism.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Horinouchi, M., Kasuga, K., Nojiri, H., Yamane, H., Omori, T.
    Cloning and characterization of genes encoding an enzyme which oxidizes dimethyl sulfide in Acinetobacter sp. strain 20B.
    FEMS Microbiol. Lett. 155 : 99-105 (1997). [PMID: 9345770]
  2. Horinouchi, M., Yoshida, T., Nojiri, H., Yamane, H., Omori, T.
    Polypeptide Requirement of Multicomponent Monooxygenase DsoABCDEF for Dimethyl Sulfide Oxidizing Activity.
    Biosci. Biotechnol. Biochem. 63 : 1765-1771 (1999). [PMID: 26300166]

[EC created 2019]