EC 1.14.13.244 - Phenol 2-monooxygenase (NADH)

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IntEnz Enzyme Nomenclature
EC 1.14.13.244

Names

Accepted name:
phenol 2-monooxygenase (NADH)
Systematic name:
phenol,NADH:oxygen oxidoreductase (2-hydroxylating)

Reaction

Comments:

The enzyme, characterized from the bacteria Pseudomonas sp. CF600 and Acinetobacter radioresistens, consists of a multisubunit oxygenease component that contains the active site and a dinuclear iron center, a reductase component that contains FAD and one iron-sulfur cluster, and a regulatory component. The reductase component is responsible for transferring electrons from NADH to the dinuclear iron center.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Nordlund, I., Powlowski, J., Shingler, V.
    Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
    J. Bacteriol. 172 : 6826-6833 (1990). [PMID: 2254258]
  2. Powlowski, J., Shingler, V.
    In vitro analysis of polypeptide requirements of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
    J. Bacteriol. 172 : 6834-6840 (1990). [PMID: 2254259]
  3. Powlowski, J., Sealy, J., Shingler, V., Cadieux, E.
    On the role of DmpK, an auxiliary protein associated with multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
    J. Biol. Chem. 272 : 945-951 (1997). [PMID: 8995386]
  4. Qian, H., Edlund, U., Powlowski, J., Shingler, V., Sethson, I.
    Solution structure of phenol hydroxylase protein component P2 determined by NMR spectroscopy.
    Biochemistry 36 : 495-504 (1997). [PMID: 9012665]
  5. Cadieux, E., Vrajmasu, V., Achim, C., Powlowski, J., Munck, E.
    Biochemical, Mossbauer, and EPR studies of the diiron cluster of phenol hydroxylase from Pseudomonas sp. strain CF 600.
    Biochemistry 41 : 10680-10691 (2002). [PMID: 12186554]

[EC 1.14.13.244 created 2019]