EC 1 - Oxidoreductases
EC 1.14 - Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2
EC 1.14.13 - With NADH or NADPH as one donor, and incorporation of one atom of oxygen
EC 1.14.13.223 - 3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.14.13.223
Names
Accepted name:
3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase
Other
name:
sibG (gene name)
Systematic name:
3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein],NADH:oxygen oxidoreductase (5-hydroxylating)
Reaction
- 3-hydroxy-4-methyl-anthranilyl-aryl-carrier protein + NADH + H+ + O2 = 3,5-dihydroxy-4-methyl-anthranilyl-aryl-carrier protein + NAD+ + H2O
Cofactor
Comments:
A flavoprotein (FAD). The enzyme, characterized from the bacterium Streptosporangium sibiricum, is involved in the biosynthesis of the antitumor antibiotic sibiromycin. The enzyme is not active with free 3-hydroxy-4-methylanthranilate.
Links to other databases
UniProtKB/Swiss-Prot:
SIBG_STRSJ
References
-
A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin.Biochemistry 50 : 5680-5692 (2011). [PMID: 21612226]
[EC 1.14.13.223 created 2016]