EC 1.14 - Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2
EC 18.104.22.168 - 3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase
IntEnz Enzyme Nomenclature
- 3-hydroxy-4-methyl-anthranilyl-aryl-carrier protein + NADH + H+ + O2 = 3,5-dihydroxy-4-methyl-anthranilyl-aryl-carrier protein + NAD+ + H2O
A flavoprotein (FAD). The enzyme, characterized from the bacterium Streptosporangium sibiricum, is involved in the biosynthesis of the antitumor antibiotic sibiromycin. The enzyme is not active with free 3-hydroxy-4-methylanthranilate.
Links to other databases
A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin.Biochemistry 50 : 5680-5692 (2011). [PMID: 21612226]
[EC 22.214.171.124 created 2016]