EC 1.14.13.215 - Protoasukamycin 4-monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.215

Names

Accepted name:
protoasukamycin 4-monooxygenase
Systematic name:
protoasukamycin,NADH:oxygen oxidoreductase (4-hydroxylating)

Reaction

Cofactor

Comments:

The enzyme, characterized from the bacterium Streptomyces nodosus subsp. asukaensis, is involved in the biosynthesis of the antibiotic asukamycin. Requires a flavin cofactor, with no preference among FMN, FAD or riboflavin. When flavin concentration is low, activity is enhanced by the presence of the NADH-dependent flavin-reductase AsuE2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Rui, Z., Sandy, M., Jung, B., Zhang, W.
    Tandem enzymatic oxygenations in biosynthesis of epoxyquinone pharmacophore of manumycin-type metabolites.
    Chem. Biol. 20 : 879-887 (2013). [PMID: 23890006]

[EC 1.14.13.215 created 2016]