EC - Rifampicin monooxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
rifampicin monooxygenase
Other name:
Systematic name:
rifampicin:NAD(P)H:oxygen oxidoreductase (2'-N-hydroxyrifampicin-forming)



The enzyme has been found in the Corynebacteria Rhodococcus equi and Nocardia farcinica. It confers increased resistance to the antibiotic rifampicin by initiating its degradation.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Andersen, S. J., Quan, S., Gowan, B., Dabbs, E. R.
    Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic.
    Antimicrob. Agents Chemother. 41 : 218-221 (1997). [PMID: 8980786]
  2. Hoshino, Y., Fujii, S., Shinonaga, H., Arai, K., Saito, F., Fukai, T., Satoh, H., Miyazaki, Y., Ishikawa, J.
    Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance.
    J. Antibiot. 63 : 23-28 (2010). [PMID: 19942945]

[EC created 2016]