EC 1.14.13.211 - Rifampicin monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.211

Names

Accepted name:
rifampicin monooxygenase
Other name:
RIF-O
Systematic name:
rifampicin:NAD(P)H:oxygen oxidoreductase (2'-N-hydroxyrifampicin-forming)

Reaction

Comments:

The enzyme has been found in the Corynebacteria Rhodococcus equi and Nocardia farcinica. It confers increased resistance to the antibiotic rifampicin by initiating its degradation.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Andersen, S. J., Quan, S., Gowan, B., Dabbs, E. R.
    Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic.
    Antimicrob. Agents Chemother. 41 : 218-221 (1997). [PMID: 8980786]
  2. Hoshino, Y., Fujii, S., Shinonaga, H., Arai, K., Saito, F., Fukai, T., Satoh, H., Miyazaki, Y., Ishikawa, J.
    Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance.
    J. Antibiot. 63 : 23-28 (2010). [PMID: 19942945]

[EC 1.14.13.211 created 2016]