EC 1.14.13.18 - 4-hydroxyphenylacetate 1-monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.18

Names

Accepted name:
4-hydroxyphenylacetate 1-monooxygenase
Other names:
4-HPA 1-hydroxylase
4-hydroxyphenylacetate 1-hydroxylase
4-hydroxyphenylacetic 1-hydroxylase
Systematic name:
4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)

Reactions

Cofactor

Comments:

A flavoprotein (FAD). Also acts on 4-hydroxyhydratropate (forming 2-methylhomogentisate) and on 4-hydroxyphenoxyacetate (forming hydroquinone and glycolate).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018665
CAS Registry Number: 55326-44-8

References

  1. Hareland, W.A., Crawford, R.L., Chapman, P.J. and Dagley, S.
    Metabolic function and properties of 4-hydroxyphenylacetic acid 1-hydroxylase from Pseudomonas acidovorans.
    J. Bacteriol. 121: 272-285 (1975). [PMID: 234937]

[EC 1.14.13.18 created 1976]