EC - 7-methylxanthine demethylase

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IntEnz Enzyme Nomenclature


Accepted name:
7-methylxanthine demethylase
Systematic name:
7-methylxanthine:oxygen oxidoreductase (demethylating)




A non-heme iron oxygenase. NADH is the preferred cofactor. Part of the caffeine degradation pathway in Pseudomonas putida. The enzyme is specific for 7-methylxanthine [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Summers, R. M., Louie, T. M., Yu, C. L., Subramanian, M.
    Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids as sole carbon and nitrogen source.
    Microbiology 157 : 583-592 (2011). [PMID: 20966097]
  2. Summers, R. M., Louie, T. M., Yu, C. L., Gakhar, L., Louie, K. C., Subramanian, M.
    Novel, highly specific N-demethylases enable bacteria to live on caffeine and related purine alkaloids.
    J. Bacteriol. 194 : 2041-2049 (2012). [PMID: 22328667]

[EC created 2011]