EC - 3-(3-hydroxy-phenyl)propanoic acid hydroxylase

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IntEnz Enzyme Nomenclature


Accepted name:
3-(3-hydroxy-phenyl)propanoic acid hydroxylase
Other name:
mhpA (gene name)
Systematic name:
3-(3-hydroxyphenyl)propanoic acid,NADH:oxygen oxidoreductase (2-hydroxylating)




A flavoprotein (FAD). This enzyme participates in a meta-cleavage pathway employed by the bacterium Escherichia coli for the degradation of various phenylpropanoid compounds.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008688
UniProtKB/Swiss-Prot: (31) [show] [UniProt]


  1. Burlingame, R., Chapman, P. J.
    Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli.
    J. Bacteriol. 155 : 113-121 (1983). [PMID: 6345502]
  2. Burlingame, R. P., Wyman, L., Chapman, P. J.
    Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation.
    J. Bacteriol. 168 : 55-64 (1986). [PMID: 3531186]
  3. Ferrandez, A., Garcia, J. L., Diaz, E.
    Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
    J. Bacteriol. 179 : 2573-2581 (1997). [PMID: 9098055]
  4. Diaz, E., Ferrandez, A., Garcia, J. L.
    Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
    J. Bacteriol. 180 : 2915-2923 (1998). [PMID: 9603882]

[EC created 2011]