EC 1.14.13.114 - 6-hydroxynicotinate 3-monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.114

Names

Accepted name:
6-hydroxynicotinate 3-monooxygenase
Other names:
NicC
6HNA monooxygenase
HNA-3-monooxygenase
Systematic name:
6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)

Reaction

Cofactor

Comments:

A flavoprotein (FAD) [1]. The reaction is involved in the aerobic catabolism of nicotinic acid.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043731
UniProtKB/Swiss-Prot:

References

  1. Nakano, H., Wieser, M., Hurh, B., Kawai, T., Yoshida, T., Yamane, T., Nagasawa, T.
    Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5.
    Eur. J. Biochem. 260: 120-126 (1999). [PMID: 10091591]
  2. Jimenez, J. I., Canales, A., Jimenez-Barbero, J., Ginalski, K., Rychlewski, L., Garcia, J. L., Diaz, E.
    Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.
    Proc. Natl. Acad. Sci. USA 105: 11329-11334 (2008). [PMID: 18678916]

[EC 1.14.13.114 created 2010]