EC 1.14.13.113 - FAD-dependent urate hydroxylase

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IntEnz Enzyme Nomenclature
EC 1.14.13.113

Names

Accepted name:
FAD-dependent urate hydroxylase
Other names:
HpxO enzyme
FAD-dependent urate oxidase
urate hydroxylase
Systematic name:
urate,NADH:oxygen oxidoreductase (5-hydroxyisourate forming)

Reaction

Cofactor

Comments:

A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC 1.7.3.3, factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC 3.5.2.17, hydroxyisourate hydrolase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102099
UniProtKB/Swiss-Prot:

References

  1. O'Leary, S. E., Hicks, K. A., Ealick, S. E., Begley, T. P.
    Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase.
    Biochemistry 48: 3033-3035 (2009). [PMID: 19260710]

[EC 1.14.13.113 created 2010]