EC - trans-cinnamate 4-monooxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
trans-cinnamate 4-monooxygenase
Other names:
t-cinnamic acid hydroxylase
trans-cinnamate 4-hydroxylase
trans-cinnamic acid 4-hydroxylase
cinnamate 4-hydroxylase
cinnamate 4-monooxygenase
cinnamate hydroxylase
cinnamic 4-hydroxylase
cinnamic acid 4-hydroxylase
cinnamic acid 4-monooxygenase
cinnamic acid p-hydroxylase
cytochrome P450 cinnamate 4-hydroxylase
hydroxylase, cinnamate 4-
oxygenase, cinnamate 4-mono-
Systematic name:
trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)




NADH also acts, more slowly. Involves a heme-thiolate protein (P-450).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016710
CAS Registry Number: 9077-75-2
UniProtKB/Swiss-Prot: (14) [show] [UniProt]


  1. Potts, J.R.M., Weklych, R. and Conn, E.E.
    The 4-hydroxylation of cinnamic acid by sorghum microsomes and the requirement for cytochrome P-450.
    J. Biol. Chem. 249: 5019-5026 (1974). [PMID: 4153152]
  2. Russell, D.W. and Conn, E.E.
    The cinnamic acid 4-hydroxylase of pea seedlings.
    Arch. Biochem. Biophys. 122: 256-268 (1967). [PMID: 4383827]

[EC created 1976]