EC 1.14.13.105 - Monocyclic monoterpene ketone monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.105

Names

Accepted name:
monocyclic monoterpene ketone monooxygenase
Other names:
1-hydroxy-2-oxolimonene 1,2-monooxygenase
dihydrocarvone 1,2-monooxygenase
MMKMO
Systematic name:
(−)-menthone,NADPH:oxygen oxidoreductase

Reactions

Cofactor

Comments:

A flavoprotein (FAD). This Baeyer-Villiger monooxygenase enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 has wide substrate specificity, catalysing the lactonization of a large number of monocyclic monoterpene ketones and substituted cyclohexanones [2]. Both (1R,4S)- and (1S,4R)-1-hydroxymenth-8-en-2-one are metabolized, with the lactone product spontaneously rearranging to form 3-isopropenyl-6-oxoheptanoate [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. van der Werf, M.J., Swarts, H.J. and de Bont, J.A.M.
    Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene.
    Appl. Environ. Microbiol. 65: 2092-2102 (1999). [PMID: 10224006]
  2. Van Der Werf, M.J.
    Purification and characterization of a Baeyer-Villiger mono-oxygenase from Rhodococcus erythropolis DCL14 involved in three different monocyclic monoterpene degradation pathways.
    Biochem. J. 347: 693-701 (2000). [PMID: 10769172]
  3. van der Werf, M.J. and Boot, A.M.
    Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14.
    Microbiology 146: 1129-1141 (2000). [PMID: 10832640]

[EC 1.14.13.105 created 2008]