EC 1 - Oxidoreductases
EC 1.14 - Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2
EC 1.14.13 - With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Contents
salicylate 1-monooxygenase
4-hydroxybenzoate 3-monooxygenase
4-hydroxyphenylacetate 3-monooxygenase. Now EC 1.14.14.9, 4-hydroxyphenylacetate 3-monooxygenase.
melilotate 3-monooxygenase
imidazoleacetate 4-monooxygenase
orcinol 2-monooxygenase
phenol 2-monooxygenase (NADPH)
flavin-containing monooxygenase
kynurenine 3-monooxygenase
2,6-dihydroxypyridine 3-monooxygenase
trans-cinnamate 4-monooxygenase, Now EC 1.14.14.91, trans-cinnamate 4-monooxygenase
benzoate 4-monooxygenase. Now EC 1.14.14.92, benzoate 4-monooxygenase
calcidiol 1-monooxygenase. Now classified as EC 1.14.15.18, calcidiol 1-monooxygenase
trans-cinnamate 2-monooxygenase
cholestanetriol 26-monooxygenase, now classified as EC 1.14.15.15, cholestanetriol 26-monooxygenase.
cyclopentanone monooxygenase
cholesterol 7alpha-monooxygenase, now classified as EC 1.14.14.23, cholesterol 7alpha-monooxygenase
4-hydroxyphenylacetate 1-monooxygenase
taxifolin 8-monooxygenase
2,4-dichlorophenol 6-monooxygenase
flavonoid 3'-monooxygenase. Now EC 1.14.14.82, flavonoid 3'-monooxygenase
cyclohexanone monooxygenase
3-hydroxybenzoate 4-monooxygenase
3-hydroxybenzoate 6-monooxygenase
methane monooxygenase (soluble)
Now classified as EC 1.14.18.4, phosphatidylcholine 12-monooxygenase.
4-aminobenzoate 1-monooxygenase
3,9-dihydroxypterocarpan 6a-monooxygenase. Now EC 1.14.14.93, 3,9-dihydroxypterocarpan 6a-monooxygenase
4-nitrophenol 2-monooxygenase
leukotriene-B4 20-monooxygenase, Now EC 1.14.14.94, leukotriene-B4 20-monooxygenase
2-nitrophenol 2-monooxygenase
albendazole monooxygenase
4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
leukotriene-E4 20-monooxygenase
anthranilate 3-monooxygenase (deaminating)
5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase. Now EC 1.14.14.96, 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase
methyltetrahydroprotoberberine 14-monooxygenase. Now EC 1.14.14.97, methyltetrahydroprotoberberine 14-monooxygenase
anhydrotetracycline 6-monooxygenase
nitric-oxide synthase (NADPH)
anthraniloyl-CoA monooxygenase
tyrosine N-monooxygenase. Now EC 1.14.14.36, tyrosine N-monooxygenase
(deleted)
questin monooxygenase
2-hydroxybiphenyl 3-monooxygenase
Now EC 1.14.18.2
(−)-menthol monooxygenase
(S)-limonene 3-monooxygenase. Now EC 1.14.14.99, (S)-limonene 3-monooxygenase
(S)-limonene 6-monooxygenase. Now classified as EC 1.14.14.51, (S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase. Now classified as EC 1.14.14.52, (S)-limonene 7-monooxygenase
pentachlorophenol monooxygenase
6-oxocineole dehydrogenase
isoflavone 3-hydroxylase. Now EC 1.14.14.88, isoflavone 3-hydroxylase
4-methoxyisoflavone 2-hydroxylase. Now EC 1.14.14.89, 4-methoxyisoflavone 2-hydroxylase
ketosteroid monooxygenase
protopine 6-monooxygenase. Now EC 1.14.14.98, protopine 6-monooxygenase
dihydrosanguinarine 10-monooxygenase. Now EC 1.14.14.100, dihydrosanguinarine 10-monooxygenase
dihydrochelirubine 12-monooxygenase. Now EC 1.14.14.101, dihydrochelirubine 12-monooxygenase
benzoyl-CoA 3-monooxygenase
L-lysine N6-monooxygenase (NADPH)
Now included with EC 1.14.14.29, 25-hydroxycholesterol 7alpha-hydroxylase
2-hydroxyquinoline 8-monooxygenase
4-hydroxyquinoline 3-monooxygenase
3-hydroxyphenylacetate 6-hydroxylase
4-hydroxybenzoate 1-hydroxylase
(deleted)
2-hydroxycyclohexanone 2-monooxygenase
quinine 3-monooxygenase. Now EC 1.14.14.55, quinine 3-monooxygenase
4-hydroxyphenylacetaldehyde oxime monooxygenase, now EC 1.14.14.37, 4-hydroxyphenylacetaldehyde oxime monooxygenase
alkene monooxygenase
sterol 14alpha-demethylase. Now EC 1.14.14.154, sterol 14alpha-demethylase
N-methylcoclaurine 3'-monooxygenase. Now EC 1.14.14.102, N-methylcoclaurine 3'-monooxygenase
methylsterol monooxygenase. Now classified as EC 1.14.18.9, methylsterol monooxygenase
tabersonine 16-hydroxylase. Now EC 1.14.14.103, tabersonine 16-hydroxylase
7-deoxyloganin 7-hydroxylase. Now EC 1.14.14.85, 7-deoxyloganin 7-hydroxylase
vinorine hydroxylase. Now EC 1.14.14.104, vinorine hydroxylase
taxane 10beta-hydroxylase. Now EC 1.14.14.105, taxane 10beta-hydroxylase
taxane 13alpha-hydroxylase. Now EC 1.14.14.106, taxane 13alpha-hydroxylase
ent-kaurene oxidase. Now EC 1.14.14.86, ent-kaurene monooxygenase
ent-kaurenoic acid oxidase. Now EC 1.14.14.107, ent-kaurenoic acid oxidase
(R)-limonene 6-monooxygenase. Now classified as EC 1.14.14.53, (R)-limonene 6-monooxygenase
magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
vanillate monooxygenase
precorrin-3B synthase
4-hydroxyacetophenone monooxygenase
glyceollin synthase. Now EC 1.14.14.135, glyceollin synthase
(deleted)
licodione synthase. Now EC 1.14.14.140, licodione synthase
flavanoid 3',5'-hydroxylase. Now EC 1.14.14.81, flavanoid 3',5'-hydroxylase
isoflavone 2-hydroxylase. Now EC 1.14.14.90, isoflavone 2-hydroxylase
zeaxanthin epoxidase. Now classified as EC 1.14.15.21, zeaxanthin epoxidase
deoxysarpagine hydroxylase. Now EC 1.14.14.136, deoxysarpagine hydroxylase
phenylacetone monooxygenase
(+)-abscisic acid 8-hydroxylase. Now EC 1.14.14.137, (+)-abscisic acid 8-hydroxylase
lithocholate 6beta-hydroxylase. Now EC 1.14.14.138, lithocholate 6beta-hydroxylase
Now EC 1.14.18.8, 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase. Now EC 1.14.14.139, 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
taurochenodeoxycholate 6alpha-hydroxylase. Now EC 1.14.14.57, taurochenodeoxycholate 6alpha-hydroxylase
cholesterol 24-hydroxylase, Now EC 1.14.14.25, cholesterol 24-hydroxylase
24-hydroxycholesterol 7alpha-hydroxylase, now classified as EC 1.14.14.26, 24-hydroxycholesterol 7alpha-hydroxylase
25/26-hydroxycholesterol 7alpha-hydroxylase. Now classified as EC 1.14.14.29, 25/26-hydroxycholesterol 7alpha-hydroxylase
senecionine N-oxygenase
psoralen synthase. Now EC 1.14.14.141, psoralen synthase
8-dimethylallylnaringenin 2-hydroxylase. Now EC 1.14.14.142, 8-dimethylallylnaringenin 2-hydroxylase
(+)-menthofuran synthase. Now EC 1.14.14.143, (+)-menthofuran synthase
monocyclic monoterpene ketone monooxygenase
epi-isozizaene 5-monooxygenase, now classified as EC 1.14.15.39, epi-isozizaene 5-monooxygenase.
limonene 1,2-monooxygenase
abieta-7,13-diene hydroxylase. Now EC 1.14.14.144, abieta-7,13-diene hydroxylase
abieta-7,13-dien-18-ol hydroxylase. Now EC 1.14.14.145, abieta-7,13-dien-18-ol hydroxylase
geranylgeraniol 18-hydroxylase. Now EC 1.14.14.146, geranylgeraniol 18-hydroxylase
methanesulfonate monooxygenase (NADH)
3-epi-6-deoxocathasterone 23-monooxygenase. Now EC 1.14.14.147, 3-epi-6-deoxocathasterone 23-monooxygenase
FAD-dependent urate hydroxylase
6-hydroxynicotinate 3-monooxygenase
angelicin synthase. Now EC 1.14.14.148, angelicin synthase
geranylhydroquinone 3-hydroxylase. Now EC 1.14.14.174, geranylhydroquinone 3-hydroxylase.
isoleucine N-monooxygenase, Now EC 1.14.14.39, isoleucine N-monooxygenase
valine N-monooxygenase. Now EC 1.14.14.38, valine N-monooxygenase
5-epiaristolochene 1,3-dihydroxylase. Now EC 1.14.14.149, 5-epiaristolochene 1,3-dihydroxylase
costunolide synthase. Now EC 1.14.14.150, costunolide synthase
premnaspirodiene oxygenase. Now EC 1.14.14.151, premnaspirodiene oxygenase
chlorophyllide a oxygenase
germacrene A hydroxylase. Now EC 1.14.14.95, germacrene A hydroxylase
phenylalanine N-monooxygenase, now classified as EC 1.14.14.40, phenylalanine N-monooxygenase
tryptophan N-monooxygenase. Now EC 1.14.14.156, tryptophan N-monooxygenase
vitamin D3 24-hydroxylase, now classified as EC 1.14.15.16, vitamin D3 24-hydroxylase
3-(3-hydroxy-phenyl)propanoic acid hydroxylase
7-methylxanthine demethylase
beta-carotene 3-hydroxylase. Now EC 1.14.15.24, beta-carotene 3-hydroxylase.
pyrrole-2-carboxylate monooxygenase
dissimilatory dimethyl-sulfide monooxygenase
Now EC 1.14.14.17, squalene monooxygenase
pentalenene oxygenase. Now EC 1.14.15.32, pentalenene oxygenase
beta-amyrin 11-oxidase. Now EC 1.14.14.152, beta-amyrin 11-oxidase
1-hydroxy-2-naphthoate hydroxylase
2-hydroxyisoflavanone synthase. Now EC 1.14.14.87, 2-hydroxyisoflavanone synthase
indole-2-monooxygenase. Now EC 1.14.14.153, indole-2-monooxygenase
indolin-2-one monooxygenase. Now EC 1.14.14.157, indolin-2-one monooxygenase
3-hydroxyindolin-2-one monooxygenase. Now EC 1.14.14.109, 3-hydroxyindolin-2-one monooxygenase
2-hydroxy-1,4-benzoxazin-3-one monooxygenase. Now EC 1.14.14.110, 2-hydroxy-1,4-benzoxazin-3-one monooxygenase.
cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]. Now EC 1.14.15.29, cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
3-ketosteroid 9alpha-monooxygenase. Now EC 1.14.15.30, 3-ketosteroid 9alpha-monooxygenase
ent-isokaurene C2-hydroxylase. Now EC 1.14.14.76 ent-isokaurene C2/C3-hydroxylase
9beta-pimara-7,15-diene oxidase. Now EC 1.14.14.111, 9beta-pimara-7,15-diene oxidase.
ent-cassa-12,15-diene 11-hydroxylase. Now EC 1.14.14.112, ent-cassa-12,15-diene 11-hydroxylase.
taxoid 14β-hydroxylase
taxoid 7β-hydroxylase
trimethylamine monooxygenase
phenylacetyl-CoA 1,2-epoxidase
alpha-humulene 10-hydroxylase. Now EC 1.14.14.113, alpha-humulene 10-hydroxylase.
linalool 8-monooxygenase. Now EC 1.14.14.84, linalool 8-monooxygenase
geraniol 8-hydroxylase. Now EC 1.14.14.83, geraniol 8-hydroxylase
(+)-sabinene 3-hydroxylase
erythromycin 12 hydroxylase
α-pinene monooxygenase
1,8-cineole 2-endo-monooxygenase. Now EC 1.14.14.133, 1,8-cineole 2-endo-monooxygenase
1,8-cineole 2-exo-monooxygenase. Now EC 1.14.14.56, 1,8-cineole 2-exo-monooxygenase
amorpha-4,11-diene 12-monooxygenase. Now EC 1.14.14.114, amorpha-4,11-diene 12-monooxygenase.
vitamin D 25-hydroxylase, now classified as EC 1.14.14.24, vitamin D 25-hydroxylase
(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase
(+)-camphor 6-exo-hydroxylase
2,5-diketocamphane 1,2-monooxygenase. Now EC 1.14.14.108, 2,5-diketocamphane 1,2-monooxygenase
6-hydroxy-3-succinoylpyridine 3-monooxygenase
The enzyme was discovered at the public-review stage to have been misclassified and was transferred to EC 1.13.11.65, carotenoid isomerooxygenase
nitric-oxide synthase [NAD(P)H]. Now classified as EC 1.14.14.47, nitric-oxide synthase (flavodoxin)
4-nitrocatechol 4-monooxygenase
4-nitrophenol 4-monooxygenase
indole-3-pyruvate monooxygenase
Now EC 1.14.18.5, sphingolipid C4-monooxygenase
pentalenolactone D synthase
neopentalenolactone D synthase
salicylate 5-hydroxylase
11-oxo-beta-amyrin 30-oxidase. Now EC 1.14.14.115, 11-oxo-beta-amyrin 30-oxidase.
averantin hydroxylase. Now EC 1.14.14.116, averantin hydroxylase
aflatoxin B synthase. Now EC 1.14.14.117, aflatoxin B synthase
tryprostatin B 6-hydroxylase. Now EC 1.14.14.118, tryprostatin B 6-hydroxylase
fumitremorgin C monooxygenase. Now EC 1.14.14.119, fumitremorgin C monooxygenase
methylxanthine N1-demethylase
methylxanthine N3-demethylase
aklavinone 12-hydroxylase
13-deoxydaunorubicin hydroxylase
2-heptyl-3-hydroxy-4(1H)-quinolone synthase
dammarenediol 12-hydroxylase. Now EC 1.14.14.120, dammarenediol 12-hydroxylase
protopanaxadiol 6-hydroxylase. Now EC 1.14.14.121, protopanaxadiol 6-hydroxylase
pikromycin synthase. Now EC 1.14.15.33, pikromycin synthase
20-oxo-5-O-mycaminosyltylactone 23-monooxygenase. Now EC 1.14.15.34, 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
L-evernosamine nitrososynthase
6-deoxyerythronolide B hydroxylase. Now EC 1.14.15.35, 6-deoxyerythronolide B hydroxylase
5-methyl-1-naphthoate 3-hydroxylase
ferruginol synthase. Now EC 1.14.14.175, ferruginol synthase
ent-sandaracopimaradiene 3-hydroxylase. Now EC 1.14.14.70, ent-sandaracopimaradiene 3-hydroxylase
oryzalexin E synthase. Now EC 1.14.14.122, oryzalexin E synthase
oryzalexin D synthase. Now EC 1.14.14.123, oryzalexin D synthase
phylloquinone omega-hydroxylase. Now EC 1.14.14.78, phylloquinone omega-hydroxylase
L-ornithine N5-monooxygenase (NADPH)
L-ornithine N5-monooxygenase [NAD(P)H]
dihydromonacolin L hydroxylase. Now EC 1.14.14.124, dihydromonacolin L hydroxylase
monacolin L hydroxylase. Now EC 1.14.14.125, monacolin L hydroxylase
docosahexaenoic acid omega-hydroxylase. Now EC 1.14.14.79, docosahexaenoic acid omega-hydroxylase
tetracenomycin A2 monooxygenase-diooxygenase
beta-amyrin 28-monooxygenase. Now EC 1.14.14.126, beta-amyrin 28-monooxygenase
methyl farnesoate epoxidase. Now EC 1.14.14.127, methyl farnesoate epoxidase
farnesoate epoxidase. Now EC 1.14.14.128, farnesoate epoxidase
long-chain acyl-CoA omega-monooxygenase. Now EC 1.14.14.129, long-chain acyl-CoA omega-monooxygenase
long-chain fatty acid omega-monooxygenase. Now EC 1.14.14.80, long-chain fatty acid omega-monooxygenase
laurate 7-monooxygenase. Now EC 1.14.14.130, laurate 7-monooxygenase
ipsdienol synthase, now classified as EC 1.14.14.31, ipsdienol synthase
benzoyl-CoA 2,3-epoxidase
salicyloyl-CoA 5-hydroxylase
4-methyl-5-nitrocatechol 5-monooxygenase
rifampicin monooxygenase
1,3,7-trimethyluric acid 5-monooxygenase
bursehernin 5-monooxygenase. Now EC 1.14.14.131, bursehernin 5-monooxygenase
()-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase. Now EC 1.14.14.132, ()-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase
protoasukamycin 4-monooxygenase
asperlicin C monooxygenase
protodeoxyviolaceinate monooxygenase
5-methylphenazine-1-carboxylate 1-monooxygenase
resorcinol 4-hydroxylase (NADPH)
resorcinol 4-hydroxylase (NADH)
cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]. Now EC 1.14.15.28, cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
aurachin C monooxygenase/isomerase
3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase
violacein synthase
F-actin monooxygenase
acetone monooxygenase (methyl acetate-forming)
propane 2-monooxygenase
jasmomic acid 12-hydroxylase
tert-butanol monooxygenase
butane monooxygenase (soluble)
tetracycline 11a-monooxygenase
6-methylpretetramide 4-monooxygenase
4-hydroxy-6-methylpretetramide 12a-monooxygenase
12-dehydrotetracycline 5-monooxygenase
indole-3-acetate monooxygenase
toluene 4-monooxygenase
aliphatic glucosinolate S-oxygenase
dimethylamine monooxygenase
carnitine monooxygenase
2-polyprenylphenol 6-hydroxylase
5-pyridoxate monooxygenase
3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase
toluene 2-monooxygenase
phenol 2-monooxygenase (NADH)
assimilatory dimethylsulfide S-monooxygenase
4β-methylsterol monooxygenase
stachydrine N-demethylase
Transferred to EC 1.14.13.124
Transferred to EC 1.14.13.125
Transferred to EC 1.14.13.127
Transferred to EC 1.14.13.126
Transferred to EC 1.14.14.42
hexahomomethionine N-hydroxylase
4-nitrophenol 2-hydroxylase
Transferred to EC 1.14.14.41
Now 1.14.13.149, phenylacetyl-CoA 1,2-epoxidase