EC 1 - Oxidoreductases
EC 1.14 - Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2
EC 1.14.12 - With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor
EC 1.14.12.19 - 3-phenylpropanoate dioxygenase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.14.12.19
Names
Accepted name:
3-phenylpropanoate dioxygenase
Other
names:
HcaA1A2CD
Hca dioxygenase
3-phenylpropionate dioxygenase
Hca dioxygenase
3-phenylpropionate dioxygenase
Systematic name:
3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating)
Reactions
- (1) 3-phenylpropanoate + NADH + H+ + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+
- (2) (2E)-3-phenylprop-2-enoate + NADH + H+ + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD+
Cofactor
Comments:
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation. It catalyses the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3-phenylprop-2-enoate.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
DIAGRAM
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00493
Gene Ontology:
GO:0008695
References
-
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.J. Bacteriol. 180 : 2915-2923 (1998). [PMID: 9603882]
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Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli.J. Bacteriol. 155 : 113-121 (1983). [PMID: 6345502]
[EC 1.14.12.19 created 2005, modified 2011]