EC - 3-phenylpropanoate dioxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
3-phenylpropanoate dioxygenase
Other names:
Hca dioxygenase
3-phenylpropionate dioxygenase
Systematic name:
3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating)




This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation. It catalyses the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3-phenylprop-2-enoate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00493
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008695
UniProtKB/Swiss-Prot: (27) [show] [UniProt]


  1. Díaz, E., Ferrández, A. and García, J.L.
    Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
    J. Bacteriol. 180 : 2915-2923 (1998). [PMID: 9603882]
  2. Burlingame, R. and Chapman, P.J.
    Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli.
    J. Bacteriol. 155 : 113-121 (1983). [PMID: 6345502]

[EC created 2005, modified 2011]