EC - 2-halobenzoate 1,2-dioxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
2-halobenzoate 1,2-dioxygenase
Other name:
2-chlorobenzoate 1,2-dioxygenase
Systematic name:
2-halobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dehalogenating, decarboxylating)




A multicomponent enzyme system composed of a dioxygenase component and an electron transfer component. The latter contains FAD. The enzyme, characterized from the bacterium Burkholderia cepacia 2CBS, has a broad substrate specificity. Substrates include 2-fluorobenzoate, 2-chlorobenzoate, 2-bromobenzoate, and 2-iodobenzoate, which are processed in this order of preference.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018626
CAS Registry Number: 125268-83-9


  1. Fetzner, S., Mueller, R. and Lingens, F.
    Degradation of 2-chlorobenzoate by Pseudomonas cepacia 2CBS.
    Biol. Chem. Hoppe-Seyler 370 : 1173-1182 (1989). [PMID: 2610934]
  2. Fetzner, S., Mueller, R., Lingens, F.
    Purification and some properties of 2-halobenzoate 1,2-dioxygenase, a two-component enzyme system from Pseudomonas cepacia 2CBS.
    J. Bacteriol. 174 : 279-290 (1992). [PMID: 1370284]
  3. Haak, B., Fetzner, S., Lingens, F.
    Cloning, nucleotide sequence, and expression of the plasmid-encoded genes for the two-component 2-halobenzoate 1,2-dioxygenase from Pseudomonas cepacia 2CBS.
    J. Bacteriol. 177 : 667-675 (1995). [PMID: 7530709]

[EC created 1992, modified 2012]