EC - [histone H3]-trimethyl-L-lysine4 demethylase

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IntEnz Enzyme Nomenclature


Accepted name:
[histone H3]-trimethyl-L-lysine4 demethylase
Systematic name:
[histone H3]-N6,N6,N6-trimethyl-L-lysine4,2-oxoglutarate:oxygen oxidoreductase



Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 4 of histone H3 (H3K4). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri-, di-, and mono-methylated forms.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034647
UniProtKB/Swiss-Prot: (34) [show] [UniProt]


  1. Seward, D. J., Cubberley, G., Kim, S., Schonewald, M., Zhang, L., Tripet, B., Bentley, D. L.
    Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins.
    Nat. Struct. Mol. Biol. 14 : 240-242 (2007). [PMID: 17310255]
  2. Klose, R. J., Yan, Q., Tothova, Z., Yamane, K., Erdjument-Bromage, H., Tempst, P., Gilliland, D. G., Zhang, Y., Kaelin, W. G.
    The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
    Cell 128 : 889-900 (2007). [PMID: 17320163]
  3. Iwase, S., Lan, F., Bayliss, P., de la Torre-Ubieta, L., Huarte, M., Qi, H. H., Whetstine, J. R., Bonni, A., Roberts, T. M., Shi, Y.
    The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.
    Cell 128 : 1077-1088 (2007). [PMID: 17320160]
  4. Christensen, J., Agger, K., Cloos, P. A., Pasini, D., Rose, S., Sennels, L., Rappsilber, J., Hansen, K. H., Salcini, A. E., Helin, K.
    RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
    Cell 128 : 1063-1076 (2007). [PMID: 17320161]

[EC created 2019]