EC 1.14.11.57 - L-proline trans-4-hydroxylase

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IntEnz Enzyme Nomenclature
EC 1.14.11.57

Names

Accepted name:
L-proline trans-4-hydroxylase
Systematic name:
L-proline,2-oxoglutarate:oxygen oxidoreductase (trans-4-hydroxylating)

Reaction

Cofactors

Comments:

Requires Fe2+ and ascorbate. The enzyme, isolated from multiple bacterial species, only produces trans-4-hydroxy-L-proline (cf. EC 1.14.11.56, L-proline cis-4-hydroxylase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Lawrence, C. C., Sobey, W. J., Field, R. A., Baldwin, J. E., Schofield, C. J.
    Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis.
    Biochem. J. 313 ( Pt 1): 185-191 (1996). [PMID: 8546682]
  2. Shibasaki, T., Mori, H., Chiba, S., Ozaki, A.
    Microbial proline 4-hydroxylase screening and gene cloning.
    Appl. Environ. Microbiol. 65: 4028-4031 (1999). [PMID: 10473412]

[EC 1.14.11.57 created 2017]