EC 1.14.11.49 - Uridine-5'-phosphate dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.11.49

Names

Accepted name:
uridine-5'-phosphate dioxygenase
Other name:
lipL (gene name)
Systematic name:
UMP,2-oxoglutarate:oxygen oxidoreductase

Reaction

Cofactor

Comments:

The enzyme catalyses a net dephosphorylation and oxidation of UMP to generate 5'-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C7-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. Requires Fe2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Yang, Z., Chi, X., Funabashi, M., Baba, S., Nonaka, K., Pahari, P., Unrine, J., Jacobsen, J. M., Elliott, G. I., Rohr, J., Van Lanen, S. G.
    Characterization of LipL as a non-heme, Fe(II)-dependent alpha-ketoglutarate:UMP dioxygenase that generates uridine-5'-aldehyde during A-90289 biosynthesis.
    J. Biol. Chem. 286: 7885-7892 (2011). [PMID: 21216959]
  2. Yang, Z., Unrine, J., Nonaka, K., Van Lanen, S. G.
    Fe(II)-dependent, uridine-5'-monophosphate alpha-ketoglutarate dioxygenases in the synthesis of 5'-modified nucleosides.
    Meth. Enzymol. 516: 153-168 (2012). [PMID: 23034228]

[EC 1.14.11.49 created 2015]