EC - Xanthine dioxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
xanthine dioxygenase
Other names:
α-ketoglutarate-dependent xanthine hydroxylase
Systematic name:
xanthine,2-oxoglutarate:oxygen oxidoreductase




Requires Fe2+ and L-ascorbate. The enzyme, which was characterized from fungi, is specific for xanthine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Cultrone, A., Scazzocchio, C., Rochet, M., Montero-Moran, G., Drevet, C., Fernandez-Martin, R.
    Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via alpha-ketoglutarate-dependent dioxygenases.
    Mol. Microbiol. 57: 276-290 (2005). [PMID: 15948966]
  2. Montero-Moran, G. M., Li, M., Rendon-Huerta, E., Jourdan, F., Lowe, D. J., Stumpff-Kane, A. W., Feig, M., Scazzocchio, C., Hausinger, R. P.
    Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans.
    Biochemistry 46: 5293-5304 (2007). [PMID: 17429948]
  3. Li, M., Muller, T. A., Fraser, B. A., Hausinger, R. P.
    Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans.
    Arch. Biochem. Biophys. 470: 44-53 (2008). [PMID: 18036331]

[EC created 2015]