EC 1.14.11.44 - (R)-dichlorprop dioxygenase (2-oxoglutarate)

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IntEnz Enzyme Nomenclature
EC 1.14.11.44

Names

Accepted name:
(R)-dichlorprop dioxygenase (2-oxoglutarate)
Other names:
RdpA
α-ketoglutarate-dependent (R)-dichlorprop dioxygenase
(R)-phenoxypropionate/α-ketoglutarate-dioxygenase
2-oxoglutarate-dependent (R)-dichlorprop dioxygenase
(R)-mecoprop dioxygenase
2-oxoglutarate-dependent (R)-mecoprop dioxygenase
Systematic name:
(R)-2-(4-chloro-2-methylphenoxy)propanoate,2-oxoglutarate:oxygen oxidoreductase (pyruvate-forming)

Reactions

Cofactor

Comments:

Fe2+-dependent enzyme. The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (R)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop [1,2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Westendorf, A., Benndorf, D., Muller, R. H., Babel, W.
    The two enantiospecific dichlorprop/alpha-ketoglutarate-dioxygenases from Delftia acidovorans MC1--protein and sequence data of RdpA and SdpA.
    Microbiol. Res. 157: 317-322 (2002). [PMID: 12501996]
  2. Muller, T. A., Fleischmann, T., van der Meer, J. R., Kohler, H. P.
    Purification and characterization of two enantioselective alpha-ketoglutarate-dependent dioxygenases, RdpA and SdpA, from Sphingomonas herbicidovorans MH.
    Appl. Environ. Microbiol. 72: 4853-4861 (2006). [PMID: 16820480]
  3. Muller, T. A., Zavodszky, M. I., Feig, M., Kuhn, L. A., Hausinger, R. P.
    Structural basis for the enantiospecificities of R- and S-specific phenoxypropionate/alpha-ketoglutarate dioxygenases.
    Protein Sci. 15: 1356-1368 (2006). [PMID: 16731970]

[EC 1.14.11.44 created 2013]