EC - 1-deoxypentalenic acid 11β-hydroxylase

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IntEnz Enzyme Nomenclature


Accepted name:
1-deoxypentalenic acid 11β-hydroxylase
Other names:
ptlH (gene name)
sav2991 (gene name)
pntH (gene name)
Systematic name:
1-deoxypentalenic acid,2-oxoglutarate:oxygen oxidoreductase




The enzyme requires Fe(II) and ascorbate. Isolated from the bacterium Streptomyces avermitilis. Part of the pathway for pentalenolactone biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. You, Z., Omura, S., Ikeda, H., Cane, D. E.
    Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis.
    J. Am. Chem. Soc. 128: 6566-6567 (2006). [PMID: 16704250]
  2. You, Z., Omura, S., Ikeda, H., Cane, D. E., Jogl, G.
    Crystal structure of the non-heme iron dioxygenase PtlH in pentalenolactone biosynthesis.
    J. Biol. Chem. 282: 36552-36560 (2007). [PMID: 17942405]

[EC created 2012]