EC - [histone H3]-lysine-36 demethylase

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IntEnz Enzyme Nomenclature


Accepted name:
[histone H3]-lysine-36 demethylase
Other names:
JmjC domain-containing histone demethylase 1A
H3-K36-specific demethylase
histone-lysine (H3-K36) demethylase
histone demethylase
protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase
Systematic name:
protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase




Requires iron(II). Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36. Lysine residues exist in three methylation states (mono-, di- and trimethylated). The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36. It can also demethylate the monomethyl- but not the trimethyl form of Lys-36.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051864
UniProtKB/Swiss-Prot: (56) [show] [UniProt]


  1. Tsukada, Y., Fang, J., Erdjument-Bromage, H., Warren, M.E., Borchers, C.H., Tempst, P. and Zhang, Y.
    Histone demethylation by a family of JmjC domain-containing proteins.
    Nature 439: 811-816 (2006). [PMID: 16362057]

[EC created 2006]