EC 1.14.11.16 - Peptide-aspartate β-dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.11.16

Names

Accepted name:
peptide-aspartate β-dioxygenase
Other names:
aspartate β-hydroxylase
aspartylpeptide β-dioxygenase
aspartyl/asparaginyl β-hydroxylase
Systematic name:
peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Reaction

Cofactor

Comments:

Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004597
CAS Registry Number: 122544-66-5
UniProtKB/Swiss-Prot:

References

  1. Gronke, R.S., Welsch, D.J., VanDusen, W.J., Garsky, V.M., Sardana, M.K., Stern, A.M. and Friedman, P.A.
    Partial purification and characterization of bovine liver aspartyl β-hydroxylase.
    J. Biol. Chem. 265: 8558-8565 (1990). [PMID: 2187868]

[EC 1.14.11.16 created 1992]