EC 1.13.99.3 - Tryptophan 2'-dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.13.99.3

Names

Accepted name:
tryptophan 2'-dioxygenase
Other names:
TSO
TSO I
TSO II
indole-3-alkane α-hydroxylase
indolyl-3-alkan α-hydroxylase
tryptophan side chain oxidase
tryptophan side chain oxidase II
tryptophan side chain oxidase type I
tryptophan side-chain α,β-oxidase
tryptophan side-chain oxidase
Systematic name:
L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)

Reaction

Cofactor

Comments:

A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050360
CAS Registry Numbers: 64295-81-4 90371-50-9

References

  1. Roberts, J. and Rosenfeld, H.J.
    Isolation, crystallization, and properties of indolyl-3-alkane α-hydroxylase. A novel tryptophan-metabolizing enzyme.
    J. Biol. Chem. 252: 2640-2647 (1977). [PMID: 15994]
  2. Takai, K., Ushiro, H., Noda, Y., Narumiya, S., Tokuyama, T. and Hayaishi, O.
    Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives.
    J. Biol. Chem. 252: 2648-2656 (1977). [PMID: 15995]

[EC 1.13.99.3 created 1984]