EC 1.13.12.15 - 3,4-dihydroxyphenylalanine oxidative deaminase

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IntEnz Enzyme Nomenclature
EC 1.13.12.15

Names

Accepted name:
3,4-dihydroxyphenylalanine oxidative deaminase
Other names:
3,4-dihydroxy-L-phenylalanine: oxidative deaminase
oxidative deaminase
DOPA oxidative deaminase
DOPAODA
Systematic name:
3,4-dihydroxy-L-phenylalanine:oxygen oxidoreductase (deaminating)

Reaction

Comments:

This enzyme is one of the three enzymes involved in L-dopa (3,4-dihydroxyphenylalanine) catabolism in the non-oxygenic phototrophic bacterium Rubrivivax benzoatilyticus OU5 (and not Rhodobacter sphaeroides OU5 as had been thought [1]), the other two being EC 4.3.1.22 (dihydroxyphenylalanine reductive deaminase) and EC 2.6.1.49 (3,4-dihydroxyphenylalanine transaminase). In addition to DOPA, the enzyme can also use L-tyrosine, L-phenylalanine, L-tryptophan and glutamate as substrate, but more slowly. The enzyme is inhibited by NADH and 2-oxoglutarate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Ranjith, N.K., Ramana, C.V. and Sasikala, C.
    Purification and characterization of 3,4-dihydroxyphenylalanine oxidative deaminase from Rhodobacter sphaeroides OU5
    Can. J. Microbiol. 54: 829-834 (2008). [PMID: 18923551]

[EC 1.13.12.15 created 2008]