EC 1.13.11.71 - Carotenoid-9',10'-cleaving dioxygenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.13.11.71

Names

Accepted name:
carotenoid-9',10'-cleaving dioxygenase
Other names:
BCO2 (gene name)
β-carotene 9',10'-monooxygenase [misleading]
Systematic name:
all-trans-β-carotene:O2 oxidoreductase (9',10'-cleaving)

Reaction

Cofactor

Comments:

Requires Fe2+. The enzyme catalyses the asymmetric oxidative cleavage of carotenoids. The mammalian enzyme can also cleave all-trans-lycopene.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102076
UniProtKB/Swiss-Prot:

References

  1. Kiefer, C., Hessel, S., Lampert, J. M., Vogt, K., Lederer, M. O., Breithaupt, D. E., von Lintig, J.
    Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A.
    J. Biol. Chem. 276: 14110-14116 (2001). [PMID: 11278918]
  2. Lindqvist, A., He, Y. G., Andersson, S.
    Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues.
    J. Histochem. Cytochem. 53: 1403-1412 (2005). [PMID: 15983114]

[EC 1.13.11.71 created 2012]