EC - Carlactone synthase

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IntEnz Enzyme Nomenclature


Accepted name:
carlactone synthase
Other names:
CCD8 (gene name)
MAX4 (gene name)
NCED8 (gene name)
Systematic name:
9-cis-10'-apo-β-carotenal:oxygen oxidoreductase (14,15-cleaving, carlactone-forming)




Requires Fe2+. The enzyme participates in a pathway leading to biosynthesis of strigolactones, plant hormones involved in promotion of symbiotic associations known as arbuscular mycorrhiza. Also catalyses EC, all-trans-10'-apo-β-carotenal 13,14-cleaving dioxygenase, but 10-fold slower.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102396


  1. Sorefan, K., Booker, J., Haurogne, K., Goussot, M., Bainbridge, K., Foo, E., Chatfield, S., Ward, S., Beveridge, C., Rameau, C., Leyser, O.
    MAX4 and RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea.
    Genes Dev. 17 : 1469-1474 (2003). [PMID: 12815068]
  2. Schwartz, S. H., Qin, X., Loewen, M. C.
    The biochemical characterization of two carotenoid cleavage enzymes from Arabidopsis indicates that a carotenoid-derived compound inhibits lateral branching.
    J. Biol. Chem. 279 : 46940-46945 (2004). [PMID: 15342640]
  3. Alder, A., Jamil, M., Marzorati, M., Bruno, M., Vermathen, M., Bigler, P., Ghisla, S., Bouwmeester, H., Beyer, P., Al-Babili, S.
    The path from beta-carotene to carlactone, a strigolactone-like plant hormone.
    Science 335 : 1348-1351 (2012). [PMID: 22422982]

[EC created 2012]