EC - Linoleate 9S-lipoxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
linoleate 9S-lipoxygenase
Other names:
linoleate 9-lipoxygenase
LOX1 (gene name)
Systematic name:
linoleate:oxygen 9S-oxidoreductase




Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and α-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (30) [show] [UniProt]


  1. Vellosillo, T., Martinez, M., Lopez, M. A., Vicente, J., Cascon, T., Dolan, L., Hamberg, M., Castresana, C.
    Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade.
    Plant Cell 19: 831-846 (2007). [PMID: 17369372]
  2. Boeglin, W. E., Itoh, A., Zheng, Y., Coffa, G., Howe, G. A., Brash, A. R.
    Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases.
    Lipids 43: 979-987 (2008). [PMID: 18795358]
  3. Andreou, A. Z., Hornung, E., Kunze, S., Rosahl, S., Feussner, I.
    On the substrate binding of linoleate 9-lipoxygenases.
    Lipids 44: 207-215 (2009). [PMID: 19037675]
  4. Bannenberg, G., Martinez, M., Hamberg, M., Castresana, C.
    Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.
    Lipids 44: 85-95 (2009). [PMID: 18949503]

[EC created 2011]